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But recent studies demonstrate significant improvement in disease-free survival and overall survival for patients with advanced colon and rectal cancer who receive adjuvant therapy. Surgery alone is inadequate therapy in as many as 50% of patients.Although increase in OS remains the ultimate goal of many clinical trials, the choice of OS benefit as a mandatory requirement to register new compounds can lead to a serious underestimation of a drug&amp;amp;amp;amp;amp;amp;amp;#39;s real efficacy.
While several phase II studies have been finalized or are in progress, no...
more Clinical investigation of autologous hematopoietic stem cell transplantation (HSCT) as therapy for multiple sclerosis (MS) has been ongoing for over a decade.
The success of clinical trials depends profoundly on clinical research coordinators as they play a key role in the executions of trial procedures.
Therefore, the demand for experienced and qualified clinical research coordinators is extremely high.
statistical power, cross-over, magnitude of the effect on RR and TTP, non-tumor-related deaths) were systematically reviewed in the trials, and the detectable 1-year OS difference, assuming a statistical power of 80%, was calculated for each.
None of these reasons for the lack of OS advantage in presence of RR and TTP benefits convincingly explained the results of the evaluated trials.Objective Our primary goal was to design and test the feasibility of a clinical trial protocol that would address the main critiques of MT trialspreviously reported in the literature.Methods We conducted a literature review guided by the questions: (1) What is the set of indicators and tools that can be used to measureeffectiveness of MT for seniors in palliative care and EOL settings?The consent rate was 55% with70% of participants completing all MT sessions.All participants completed more than 60% of questionnaires.Purpose: Because of the high cost of hepatic Overall Survival Is Not a Realistic End Point for Clinical Trials of New Drugs in Advanced Solid Tumors: A Critical Assessment Based on Recently Reported Phase III Trials in Colorectal and Breast Cancer... Memorial Sloan-Kettering Cancer Center, New York, NY. University of California San Francisco, San Francisco, CA. Four phase III clinical trials comparing a fluorouracil-based regimen with the same regimen plus either CPT-11 or oxaliplatin in advanced colorectal cancer patients were reviewed. Memorial Sloan-Kettering Cancer Center, New York, NY. University of California San Francisco, San Francisco, CA. Postoperative chemotherapy with fluorouracil and levamisole is the standard of care for patients with stage III colon cancer, and postoperative high-dose pelvic radiation combined with fluorouracil is the standard regimen for patients with stage II and III rectal cancer.This article will describe the duties of clinical research coordinators, discuss how to stimulate their performance, and explore the training impact on CRCs.Hematopoietic Stem Cell Transplantation for Myelodysplastic Syndrome and Chronic Myelomonocytic Leukemia: Comparison of Survival in Patients With an Available Donor Compared to Patients Without a Donor in Patients Up to Age 75Clinical investigation of autologous hematopoietic stem cell transplantation (HSCT) as therapy for multiple sclerosis (MS) has been ongoing for over a decade.The primary aim of the critical assessment was to explain the lack of OS advantage observed in two of the four trials, despite the presence of increased response rate (RR) and time to progression (TTP).Four possible reasons for the lack of OS benefit (i.e.